I always wondered what would have happened had Goku been healthy when Android 16 came to Earth to destroy him. Would he have been successful? Probably not. Let's face it if there's one thing we've learned throughout the history of this series it's that no one beats Goku. Even if it means killing himself...he'll win!
Watch Goku ignore canon and go SS3 on 16 in the Dragonball Xenoverse 2 video below.